Valproate-induced hyperammonemic encephalopathy enhanced by topiramate and phenobarbitone: A case report and an update

Although sodium valproate (VPA)-induced hepatic encephalopathy is a well-recognized entity, VPA can occasionally produce encephalopathy secondary to hyperammonemia in the presence of normal hepatic function, namely read more valproate-induced non-hepatic hyperammonemic encephalopathy (VNHE).Known risk factors include therapy with multiple antiepile

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Chemical Space for Peptide-based Antimicrobials

Multidrug-resistant (MDR) bacteria represent a global public health threat, and crystal beaded candle holder antimicrobial peptides (AMPs), derived from naturally occurring linear or cyclic peptides, can provide the solution.However, most AMPs are sensitive to proteases and have poor pharmacokinetics.The EU-funded ERC Advanced Grant SPACE4AMPS aims

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